US · USD
IONS
Ionis Pharmaceuticals Inc
- Day's range
- $43.74 – $44.26
- Day's volume
- $6.1M
- 52-week range
- $43.50 – $86.50
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See how IONS weighs in your net worth, what it has paid you and how far it is from your target allocation.
Create a free accountIONS in numbers
- Market cap
- $7.3B
- P/E
- -13.00
- P/B
- 16.71
- Dividend yield (12m)
- 0.00%
IONS price history
IONS risk and return
Monthly closes adjusted for splits and distributions.
| Metric | 12 months | 36 months | 60 months |
|---|---|---|---|
| Return | -46.56% | -10.62% | +66.85% |
| Volatility (annualized) | 47.62% | 50.49% | 42.04% |
| Largest drawdown | -46.81% | -46.81% | -46.81% |
| Positive months | 5/12 | 17/36 | 31/60 |
How much did investing in IONS return?
$1,000.00 invested on 11/01/2021 would be worth $1,668.49 today.
- Value today in IONS
- $1,668.49
- Return over the period
- +66.85%
- Return per year
- +10.94%
- In the S&P 500
- $1,701.60
With dividends reinvested, before taxes and costs, at month-end closes. Past returns do not guarantee future ones.
IONS fundamentals
Valuation
- P/E-13.00
- P/B16.71
- EV/EBITDA—
- EV/EBIT-12.29
- EV/Revenue8.35
- P/EBIT-12.29
- P/S8.35
- P/OCF-14.71
- P/FCF-13.02
- Earnings yield-8.14%
- PEG ratio—
- Earnings per share-$3.40
- Book value per share$2.65
Debt
- Net debt—
- Net debt/EBITDA—
- Net debt/Equity—
- Debt/Equity—
- Current ratio7.89
- Quick ratio7.73
- Cash ratio6.51
Efficiency
- Gross margin98.17%
- EBITDA margin—
- Operating margin-68.00%
- Net margin-64.66%
- Asset turnover0.29
Profitability
- ROE-128.53%
- ROA-18.87%
- ROIC-135.16%
- Payout—
Growth
- Revenue CAGR (5 years)4.91%
- Earnings CAGR (5 years)—
- Revenue growth (year)—
- Earnings growth (year)—
- Revenue growth (quarter)—
- Earnings growth (quarter)—
IONS's indicators by year
Multiples at each year's closing price; margins and returns from that year's statements.
| Indicator | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 |
|---|---|---|---|---|---|---|---|---|
| P/E | -34.27 | -12.24 | -20.13 | -20.02 | -150.77 | -17.93 | 30.24 | 27.33 |
| P/B | 26.72 | 9.45 | 19.07 | 9.42 | 5.59 | 10.72 | 5.72 | 7.14 |
| Earnings per share | -$2.31 | -$2.86 | -$2.51 | -$1.89 | -$0.20 | -$3.15 | $2.00 | $1.98 |
| Book value per share | $2.96 | $3.70 | $2.65 | $4.01 | $5.45 | $5.28 | $10.57 | $7.57 |
| ROE | -77.98% | -77.15% | -94.72% | -47.08% | -3.71% | -59.77% | 18.91% | 26.12% |
| ROIC | — | — | — | — | -3.84% | -23.15% | 21.09% | -0.00% |
| Gross margin | 98.31% | 98.41% | 98.84% | 97.60% | 98.66% | 98.36% | 99.61% | 99.70% |
| Net margin | -40.41% | -64.37% | -46.50% | -45.92% | -3.53% | -60.92% | 24.78% | 45.65% |
IONS's financial statements
| Line | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|
| Net revenue | $943.7M | $705.1M | $787.6M | $587.4M | $810.5M | $729.3M |
| Cost of revenue | -$15.9M | -$11.2M | -$9.1M | -$14.1M | -$10.8M | -$11.9M |
| Gross profit | $927.8M | $693.9M | $778.5M | $573.3M | $799.6M | $717.3M |
| EBITDA | — | — | — | — | — | — |
| EBIT | -$381.7M | -$475.1M | -$353.7M | -$410.2M | -$30.2M | -$172.1M |
| Financial result | — | — | — | — | — | — |
| Income before tax | -$379.6M | -$460.1M | -$334M | -$258M | -$29.1M | -$134.6M |
| Income tax | -$1.8M | $6.2M | -$32.3M | -$11.7M | $551K | -$345.2M |
| Net income | -$381.4M | -$453.9M | -$366.3M | -$269.7M | -$28.6M | -$444.3M |
Figures the company filed with the CVM. Debt excludes leases; each quarter is that quarter alone.
Does IONS pay dividends?
IONS has no distributions on record.
About Ionis Pharmaceuticals
- Sector
- Manufacturing
Questions about IONS
How much is IONS today?
IONS is at $44.22 (0.49% on the day), last traded on 10/07/2026.
What are the P/E and P/B of IONS?
IONS trades at a P/E of -13.00 and a P/B of 16.71.
How much did IONS return in 12 months?
IONS returned -46.56% in 12 months, with annualized volatility of 47.62% and a largest drawdown of -46.81%.