US · USD
SYRE
Spyre Therapeutics Inc.
- Day's range
- $79.36 – $92.08
- Day's volume
- $340.2M
- 52-week range
- $16.02 – $108.92
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Create a free accountSYRE in numbers
- Market cap
- $7.1B
- P/E
- -39.48
- P/B
- 6.41
- Dividend yield (12m)
- 0.00%
SYRE price history
SYRE risk and return
Monthly closes adjusted for splits and distributions.
| Metric | 12 months | 36 months | 60 months |
|---|---|---|---|
| Return | +167.03% | +329.31% | -48.65% |
| Volatility (annualized) | 61.24% | 61.90% | 144.12% |
| Largest drawdown | -18.53% | -60.53% | -97.92% |
| Positive months | 6/12 | 20/36 | 30/60 |
How much did investing in SYRE return?
$1,000.00 invested on 11/01/2021 would be worth $513.53 today.
- Value today in SYRE
- $513.53
- Return over the period
- -48.65%
- Return per year
- -12.65%
- In the S&P 500
- $1,712.05
With dividends reinvested, before taxes and costs, at month-end closes. Past returns do not guarantee future ones.
SYRE fundamentals
Valuation
- P/E-39.48
- P/B6.41
- EV/EBITDA—
- EV/EBIT-35.08
- EV/Revenue—
- P/EBIT-35.08
- P/S—
- P/OCF-33.81
- P/FCF—
- Earnings yield-2.85%
- PEG ratio—
- Earnings per share-$2.03
- Book value per share$12.49
Debt
- Net debt—
- Net debt/EBITDA—
- Net debt/Equity—
- Debt/Equity—
- Current ratio18.53
- Quick ratio—
- Cash ratio2.56
Profitability
- ROE-16.25%
- ROA-15.25%
- ROIC-18.28%
- Payout—
SYRE's indicators by year
Multiples at each year's closing price; margins and returns from that year's statements.
| Indicator | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 |
|---|---|---|---|---|---|---|---|---|
| P/E | -16.58 | -6.75 | -2.30 | -0.35 | -3.56 | -4.67 | -2.84 | -4.87 |
| P/B | 3.60 | 2.71 | 4.23 | 0.58 | 2.79 | 2.70 | 3.70 | 3.20 |
| Earnings per share | -$1.98 | -$3.45 | -$9.37 | -$1.28 | -$1.33 | -$1.68 | -$2.69 | -$1.54 |
| Book value per share | $9.11 | $8.59 | $5.09 | $0.77 | $1.70 | $2.91 | $2.07 | $2.34 |
| ROE | -21.70% | -40.17% | -184.11% | -166.61% | -78.39% | -57.85% | -130.25% | -65.77% |
| ROIC | -29.30% | -40.28% | -131.66% | -168.26% | -78.21% | -58.27% | -133.71% | -44.50% |
| EBITDA margin | — | — | -27,264.00% | -3,572.95% | -341.92% | — | — | -1,161.78% |
| Net margin | — | — | -38,238.15% | -3,598.75% | -351.14% | — | — | -1,140.64% |
SYRE's financial statements
| Line | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|
| Net revenue | $0 | $0 | $886K | $2.3M | $18.7M | $0 |
| Cost of revenue | — | — | — | — | — | — |
| Gross profit | — | — | — | — | — | — |
| EBITDA | -$209.6M | -$208.6M | -$241.6M | -$83.2M | -$64.1M | -$80.5M |
| EBIT | -$209.6M | -$208.6M | -$242.3M | -$84.8M | -$65.6M | -$81.5M |
| Financial result | $54.3M | $599K | -$96.5M | $830K | -$11K | $588K |
| Income before tax | -$155.2M | -$208M | -$338.8M | -$84M | -$65.7M | -$80.9M |
| Income tax | $15K | -$51K | $26K | $136K | -$141K | -$0 |
| Net income | -$155.2M | -$208M | -$338.8M | -$83.8M | -$65.8M | -$80.9M |
Figures the company filed with the CVM. Debt excludes leases; each quarter is that quarter alone.
Does SYRE pay dividends?
SYRE has no distributions on record.
About Spyre Therapeutics
- Sector
- Manufacturing
Questions about SYRE
How much is SYRE today?
SYRE is at $80.11 (-13.60% on the day), last traded on 10/06/2026.
What are the P/E and P/B of SYRE?
SYRE trades at a P/E of -39.48 and a P/B of 6.41.
How much did SYRE return in 12 months?
SYRE returned 167.03% in 12 months, with annualized volatility of 61.24% and a largest drawdown of -18.53%.